no code implementations • 24 Jul 2023 • Emma Leschiera, Gheed Al-Hity, Melanie S. Flint, Chandrasekhar Venkataraman, Tommaso Lorenzi, Luis Almeida, Chloe Audebert
In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol resulted in a decreased immune cell infiltration into the spheroids.
no code implementations • 12 Jul 2021 • Emma Leschiera, Tommaso Lorenzi, Shensi Shen, Luis Almeida, Chloe Audebert
First, the results of numerical simulations of this model indicate that the presence of a larger number of sub-populations of tumour cells that express different antigens is associated with a reduced ability of CD8+ T cells to mount an effective anti-tumour immune response.
