no code implementations • 19 Oct 2023 • Jordan C. Rozum, Colin Campbell, Eli Newby, Fatemeh Sadat Fatemi Nasrollahi, Reka Albert
Modeling these systems is made challenging by the number and variety of biological components and interactions (from molecules in gene regulatory networks to species in ecological networks) and the often-incomplete state of system knowledge (e. g., the unknown values of kinetic parameters for biochemical reactions).
no code implementations • 8 Mar 2023 • Eli Newby, Jorge Gómez Tejeda Zañudo, Réka Albert
Driving a network's feedback vertex set (FVS) by node-state override into a state consistent with a target attractor is proven to force every system trajectory to the target attractor, but in biological networks, the FVS is typically larger than can be realistically manipulated.
1 code implementation • 22 Nov 2021 • Eli Newby, Jorge Gómez Tejda Zañudo, Réka Albert
Thus, we developed an approach to rank subsets of the FVS on Boolean models of intracellular networks using topological, dynamics-independent measures.