no code implementations • 17 Oct 2023 • Federica Ferretti, Mehran Kardar
We describe the evolution of the B cell population via a quasispecies dynamics, with species corresponding to unique B cell receptors (BCRs), where the desired multi-scale structure is reflected on the mutational connectivity of the accessible BCR space, and on the statistical properties of its fitness landscape.
no code implementations • 16 Jan 2021 • Federica Ferretti, Victor Chardès, Thierry Mora, Aleksandra M Walczak, Irene Giardina
Discretization of continuous stochastic processes is needed to numerically simulate them or to infer models from experimental time series.