1 code implementation • 12 Jun 2023 • Justin G. Laughlin, Jørgen S. Dokken, Henrik N. T. Finsberg, Emmet A. Francis, Christopher T. Lee, Marie E. Rognes, Padmini Rangamani
Recent advances in microscopy and 3D reconstruction methods have allowed for characterization of cellular morphology in unprecedented detail, including the irregular geometries of intracellular subcompartments such as membrane-bound organelles.
no code implementations • 2 May 2021 • Xiaoran Lai, Håkon A. Taskén, Torgeir Mo, Simon W. Funke, Arnoldo Frigessi, Marie E. Rognes, Alvaro Köhn-Luque
Coupling discrete cell-based models with continuous models using hybrid cellular automata is a powerful approach for mimicking biological complexity and describing the dynamical exchange of information across different scales.
no code implementations • 4 Feb 2021 • Ada J. Ellingsrud, Nicolas Boullé, Patrick E. Farrell, Marie E. Rognes
Mathematical modelling of ionic electrodiffusion and water movement is emerging as a powerful avenue of investigation to provide new physiological insight into brain homeostasis.
Numerical Analysis Computational Engineering, Finance, and Science Numerical Analysis
no code implementations • 9 Jun 2016 • Geir Halnes, Klas H. Pettersen, Leiv Øyehaug, Marie E. Rognes, Gaute T. Einevoll
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.